Welcome to the Evolution of Joint Health Ingredients

Times are changing and so are formulators’ needs and expectations, especially as consumers are being more proactive about their health and demanding more science. It’s time for manufacturers to say goodbye to dated joint support ingredients in their products and welcome in a new, clinically tested all-herbal formula that is truly a breakthrough in the nutraceutical industry.

Introducing Karallief® Easy Climb® – the clinically tested and fast acting natural joint  support formula featuring only pure and highly effective herbal extracts!*[1]

Karallief® Easy Climb® has been clinically shown to help improve joint comfort in as little as 30 days, promote mobility and maintain healthy joint space width.*[1]

Our patented formula is available in powdered form, as this provides maximum potency and shelf life. This delivery method also lends the most flexibility to formulators, making it easy to add our product to anything from vitamins and supplements, protein powders, recovery drinks and more. Plus, Karallief® Easy Climb® is Non-GMO Project verified and vegan, making it an exceptionally clean and natural joint support option.*

*The statements on the website have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. These products are not offered for sale to consumers. These products and information here are only intended for manufacturers for professional product development purposes.

The Karallief® Easy Climb® Clinical Study[1]

Many supplement manufacturers, distributors and consumers are often skeptical about the effectiveness of herbal ingredients for joint support, which is understandable. Very few, if any, herbal extract formulators on the market can validate their joint health claims or the purity of their ingredients, but Karallief® IS NOT one of those companies.

Karallief® believes science should drive strategy and the purity of our raw ingredients is vital.

We tested the safety and efficacy of our Karallief® Easy Climb® formula over the course of 120 days with a randomized, double-blind, parallel, placebo-controlled study on subjects with age-related knee concerns. One group of 40 participants received 1,000 mg of the Easy Climb® formula each day, and a second group of 40 subjects served as the control and received a placebo. 

The trial lasted 4 months and each subject was evaluated for improvement using the following:

• The 30 Second Chair Stand Test to assess strength and endurance

• WOMAC index for discomfort, stiffness and function

• Knee Flexion Test for range of motion

• X-ray measurement of joint space width*

The results from the clinical study were very impressive, showing just how powerful our joint support formula is.* The Karallief® Easy Climb® study participants experienced…

• 71% decrease in discomfort scores compared to the placebo at 49%*[1]

• 25% increase in joint space width, double that of 11% for the placebo*[1]

• 8% improvement in the range of knee flexion, double that of the placebo at 4%*[1]

• 16% increase in the number of times they could stand from being seated versus the placebo at 8%*[1]

The details from the clinical study are as follows:

30 SECOND CHAIR TEST

This tested the number of times the subjects could stand from a seated position within 30 seconds. For a patient to feel a significant change, the improvement should be at least as much as the minimal clinically important difference (MCID), which is a value of 2 repetitions for this test.[19] The Easy Climb® formula brought an improvement of around 2 repetitions, suggesting that it helps improve endurance and joint strength.*

• The Easy Climb® group showed a statistically significant improvement from 11.06 to 11.94 (8% increase in 60 days) and 11.06 to 12.86 (16% increase in 120 days)

• The placebo group showed a 3% increase in 60 days and an 8% increase in 120 days

WOMAC

Participants answered a questionnaire to evaluate their change in discomfort, stiffness and physical function. The overall results of this test suggest that Easy Climb® improves joint comfort and function.*

• Discomfort: After 30 days, the Easy Climb® group saw statistically significant reduction in scores of 15% compared to only a 3% decrease for the placebo group. After 4 months, there was a statistically significant decrease in both groups, however results for the Easy Climb® group was better and statistically significant over placebo.

  • The Easy Climb® group scores decreased from 5.94 to 1.74, a 71% decrease

  • The placebo group decreased from 4.41 to 2.24, a 49% decrease

KNEE FLEXION

This test measured how much the knee could flex while the subject was lying down. All groups showed a statistically significant increase in knee flexion compared to baseline, however the Easy Climb® group’s range of motion improved better and was statistically significant compared to the placebo. A normal healthy knee can flex up to 130 degrees.[20]

• The range of knee flexion for the Easy Climb® group improved from 113.68° to 122.50°, an 8% increase

• The range of knee flexion for the placebo group improved from 115.00° to 119.12°, a 4% increase

JOINT SPACE WIDTH

This tested the minimum joint space width as measured by X-rays. In a healthy knee joint, the average joint width space is 4.8mm-5.7mm.* Older subjects and/or those with knee discomfort often have less joint cartilage, thus narrowing the joint space. The Easy Climb® group results were better and statistically significant compared to placebo, demonstrating an improvement in joint space which suggests that the Easy Climb® formula contributes to overall joint health.*

• The Easy Climb® group joint space increased from 1.54 mm to 1.92 mm, a 25% improvement*

• The placebo group joint space increased from 1.52 mm to 1.69 mm, an 11% improvement*

Karallief® Easy Climb® Contains
Clean and Clinically Tested Herbal Ingredients

While there are many manufacturers who use inferior herbal extracts and make unsupported claims about their products, we are not one of them.

Karallief® uses clean, potent and clinically tested ingredients in our Easy Climb® joint support formula. Our fast-acting proprietary blend has been scientifically studied and shown to help promote joint comfort in as little as 30 days!*[1]

Our patented herbal formula is truly unlike any other natural joint support product on the market. After extensive research and testing, our team of scientists developed a unique and effective formula based on the exact ratios of specific standardized ingredients that are known for supporting healthy joints – including cartilage, tendons and bones.*  

Karallief® Easy Climb® is in a powdered form as this provides maximum potency and shelf life. In addition, this delivery method lends the most flexibility to formulators, making it easy to add our product to anything from vitamins and supplements, protein powders, beverages and more. Plus, Karallief® Easy Climb® is Non-GMO Project verified and vegan, making it a clean and natural joint support option.

Karallief® Easy Climb® contains a potent 1,000 mg per day blend of the following:

Bambusa Arundinacea
(Bamboo)
Helps with Joint Comfort & Supports Bone Health*[11,12]

Bambusa Arundinacea is predominantly made up of silica, a type of trace mineral that is concentrated in the bones and connective tissue in the body.[5] The siliceous secretion of the shoots are extracted and standardized for a proprietary composition consisting of Silibam™, which is a form of natural silica.

The Scientific Evidence:

• Contains phytocompounds such as flavonoids, alkaloids, steroids, amino acids, tannins and phenolic compounds and has been found to support joint comfort.*[11]

• Bamboo contains silica, a trace mineral in bones and connective tissue that helps maintain healthy bones, providing structural integrity to joints.*[12]

Citrus Sinensis
(Sweet Orange)
Shown to Support Capillary Resistance & Circulation[14]

Citrus Sinensis contains antioxidant compounds including hesperidin, a bioflavonoid with many biological effects. It has been shown to provide support for optimal circulation.*[14] The fruit peels are extracted and standardized for a proprietary composition consisting of Hespernoids™, which are bioflavonoids.

 The Scientific Evidence:

• It has been shown in research studies that when citrus is taken at certain doses, it has the ability to maintain capillary health, which ultimately may help support blood circulation to the joints.*[14]

• Hesperidin has been shown in animal studies that it has the unique ability to help maintain healthy bone turnover levels.[13]

Curcuma Longa
(Turmeric)
Helps Suppress Changes in Joints & Bones*[15,16,17]

A plant belonging to the ginger family, turmeric root has been used in the Ayurvedic traditional system for blood purifying and is a mainstay in Indian cooking.* The rhizomes are extracted and standardized for a proprietary composition consisting of Tursolonin™, which are a specific group of soluble saponin glycosides.

The Scientific Evidence:

• Turmeric is known for its ability to inhibit many immune system cascades in the body, including suppressing NF-kappa B,[15,16] and blocking activation of TNF-alpha, , in both in vitro and in vivo studies.*

• TNF-alpha is linked to many different health conditions including joint health.*[17]  

The Next Generation of Joint Health is Here!

The clinical study performed on Karallief® Easy Climb® shows how effective our natural herbal formula is for helping improve joint comfort and mobility, which is truly an incredible breakthrough.*[1]

As a formulator, you too can make a difference in your customers’ lives. Choose Karallief® Easy Climb® and feel confident in knowing you are using a powerful herbal blend that is safe, effective and clinically studied – plus it’s vegan and Non-GMO Project verified.

If you ever experienced challenges with adding ingredients like glucosamine to your formulas, you won’t have that with Karallief® Easy Climb®. No more large pill sizes or associated side-effects, and vegans and those with shellfish allergies will be able to take your product.

The Nutrition Business Journal published a 2020 sales analysis of various joint health ingredients that not only showed glucosamine is becoming a supplement of the past – but there is a huge sales increase in a category labelled “Other”, averaging almost $32 million each year and expected to increase to $722 million by 2023.

This category is telling us that consumers are unhappy with the common, and rather dated joint health ingredients that have been on the market for far too long, and are looking for something new, something powerful and something effective. It’s time to give consumers what they want, and that is Karallief® Easy Climb®!

Formulate your next product with Karallief® Easy Climb® – the natural, vegan and Non-GMO Project verified herbal extract formula that’s clinically shown to help improve joint comfort in as little as 30 days, promote mobility AND maintain healthy joint space width.*[1]

Our Quality Standards and Protocols

Karallief® has successfully united the powerful forces of nature, science and innovation to develop our breakthrough Easy Climb® formula.

Our company is unlike many ingredient suppliers that use inferior, untested materials that lack quality control measures. Instead, we pride ourselves on offering safe, efficacious and scientifically backed ingredients that are tested through thorough quality control procedures using high-end testing equipment.